06.12.2018 16:30:00

Press Release: Novartis investigational BYL719 -2-

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[1] Juric D, Ciruelos EM, Rubovszky G et al. Alpelisib (ALP) +

fulvestrant (FUL) for advanced breast cancer (ABC): Phase 3 SOLAR-1

trial results. Presented at the San Antonio Breast Cancer Symposium

(SABCS) (Abstract #GS3-08) on December 6, 2018.

[2] Sabine V, Crozier C, Brookes C, et al. Mutational analysis of

PI3K/AKT signaling pathway in tamoxifen exemestane adjuvant

multinational pathology study. Journal of Clinical Oncology.


[3] Miller TW, Rexer BN, Garrett JT, et al. Mutations in the

Phosphatidylinositol 3-Kinase Pathway: Role in Tumor Progression and

Therapeutic Implications in Breast Cancer. Breast Cancer Res. 2011.

[4] Saal LH, Johansson P, Holm K. Poor prognosis in carcinoma is

associated with a gene expression signature of aberrant PTEN tumor

suppressor pathway activity. PNAS. 2007;104(18):7564-7569.

[5] Fritsch C, Huang A, Chatenay-Rivauday A et al. Characterization of

the novel and specific PI3K alpha inhibitor NVP BYL719 and development

of patient stratification strategy for clinical trials. Molecular Cancer

Therapeutics.2014; 13(5):1117-1129.

*Qiagen is a registered trademark of QIAGEN N.V.

**Foundation Medicine is a registered trademark of Foundation Medicine,


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(END) Dow Jones Newswires

December 06, 2018 10:30 ET (15:30 GMT)